AKT1 and acute myeloid leukemia: Using pharmacological inhibition of Notch pathway or specific blocking antibodies, we found that Notch blockade inhibits AML proliferation and abrogates hBM-MSC-mediated AML resistance to chemotherapeutic agents through the modulation of pro-/anti-apoptotic proteins balance and levels of prosurvival proteins, including AKT, STAT3 and NF-kB.