Upregulation and downregulation of various chemokines (CCL4, CCL18, CCL27, CCR1, CCR5, CCR7, CXCL1, CXCL9, CXCL10, CXCL13 and CXCR4) involved in the recruitment of leukocytes and angiogenesis were observed to occur in both psoriasis and RA linking the immune mediated diseases [36–37]. The gene discussed is CXCL1; the disease is psoriasis.