Seven pathways involved in blood coagulation, Cadherin signaling, FGF signaling, Ionotropic glutamate receptor pathway, Metabotropic glutamate receptor group III pathway, Muscarinic acetylcholine receptor 1 and 3 signaling pathway, and Nicotinic acetylcholine receptor signaling pathway were enriched in AD,T2DM, obesity and RA. The gene discussed is CHRM1; the disease is obesity disorder.