Upregulation and downregulation of various chemokines (CCL4, CCL18, CCL27, CCR1, CCR5, CCR7, CXCL1, CXCL9, CXCL10, CXCL13 and CXCR4) involved in the recruitment of leukocytes and angiogenesis were observed to occur in both psoriasis and RA linking the immune mediated diseases [36–37]. This evidence concerns the gene CXCR4 and psoriasis.