The findings are in line with our previous proposal thatextracellular Grx1 is a predictor of impaired extracellular redox balance andimpaired coping with hyperglycemia induced oxidative stress, thus a risk markerfor DM onset and progression [8], and the finding that increased Grx1 attenuatespost-ischemia revascularization in a mouse model [9]. This evidence concerns the gene GLRX and ischemia.