Taken together, the associations of reduced FA with SZ, BD, and the rs1344706 risk allele A, suggest that WM microstructural abnormalities may be part of the pathophysiological mechanism through which ZNF804A rs1344706 (or other polymorphism(s) in high linkage disequilibrium with it) increases risk for SZ ad BD. The gene discussed is ZNF804A; the disease is Behcet disease.