The rs1344706 psychosis risk allele (i.e., A) of ZNF804A has lower binding affinity for proteins in the cell nucleus, such as transcription factors (Hill & Bray, 2011) and, potentially as a result of this, shows significantly increased expression compared to its counterpart (C allele) in healthy controls (Riley et al., 2010). This evidence concerns the gene ZNF804A and psychotic disorder.