This miR is computationally predicted to target several hundred possible mRNAs, including targets associated with type 2 diabetes (e.g., glucagon (GCG), deiodinase, iodothyronine, type II (DIO2), leptin (LEP), NK2 homeobox 2 (NKX2-2), solute carrier family 30, member 8 (SLC30A8), synapsin I (SYN1), nuclear respiratory factor 1 (NRF1), SHC transforming protein 1 (SHC1), Kruppel-like factor 12 (KLF12), protein kinase C, beta (PRKCB) [42, 43]. The gene discussed is SHC1; the disease is type 2 diabetes mellitus.