FUS and amyotrophic lateral sclerosis: Furthermore, a subset of C9ORF72 ALS cases with no FTD specifically showed p62 inclusions in the cerebral cortex, hippocampus, and cerebellum [5]. Fused in sarcoma (FUS) linked ALS is less likely to be linked with FTD, and a specific FUS mutation (R521C) is associated with earlier disease onset and increased likelihood of dropped head syndrome [6], further indicating the clinical variety.