Neutrophil depletion in two murine models of melanoma and fibrosarcoma reverts the increased tumor growth, angiogenesis, and metastasis observed in IFN-β-deficient mice with skewed N2 phenotypes [56], and recent review of the relationship between TAN infiltration and prognosis in human cancer demonstrates the function of TANs in murine and human tumor progression [57]. This evidence concerns the gene IFNB1 and neoplasm.