To note, tumor-associated myeloid cells (TAMCs) comprise five distinct myeloid populations: tumor-associated macrophages (TAMs), monocytes expressing the angiopoietin-2 receptor Tie2 (Tie2-expressing monocytes or TEMs), myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), and tumor-associated dendritic cells (Figure 1) [3]. The gene discussed is TEK; the disease is neoplasm.