PPBP and neoplasm: Clot formation by TF expressed by tumor cells enhances recruitment of macrophages in a lung metastasis model through various mechanisms including protease-activated receptor [90], and recruitment of granulocytic cells by the platelet-secreted CXCR2 ligands, CXCL5 and CXCL7 chemokines, upon platelet contact with tumor cells is essential mechanism for the guidance of granulocytes to form “early metastatic niches” [81, 91, 92].