Though we still lack evidence to support the role of platelets in activation of macrophages and neutrophils—and it is generally accepted that their tumor-protective role in the blood stream may be the most profound influence of platelets on tumor progression—thrombocytopenic mice show increased blood TNF-α and IL-6 and decreased TGF-β [87], possibly favoring antitumoral polarization; as stated, platelets are involved in recruitment of both macrophages and neutrophils in both primary and metastatic tumor sites. The gene discussed is TGFB1; the disease is neoplasm.