Five of 32 patients with best response of SD discontinued romidepsin due to the following AEs: ventricular extrasystoles and decreased T wave amplitude (probably drug related; cycle 1); neutropenia (drug related; cycle 3); acute angle-closure glaucoma (possibly drug related; cycle 4); pulmonary embolism, elevated C-reactive protein, and melanoma (only melanoma was possibly drug related; cycle 6); and pneumonia (not drug related; cycle 9). The gene discussed is CRP; the disease is melanoma.