As expected, hypoxic exposure significantly increased cancer stemness related factors (c-Myc, Klf4, Nanog, and Oct4) (Supplementary Fig. 4A) and Wnt/β-catenin signaling components (Wnt1, TCF4, and Cyclin D1) (Supplementary Fig. 4B,C). The gene discussed is POU5F1; the disease is cancer.