The postoperative pathology report confirmed the diagnosis of anaplastic astrocytoma with transformation to glioblastoma, which was immunopositive for MGMT, PTEN, GFAP, Oligo-2, MMP-9, P53 and immunonegative for EGFR, P-170, VEGF, TOPO-II, and GST-π. The gene discussed is MGMT; the disease is anaplastic astrocytoma.