CACNA1S and myotonic dystrophy type 1: Because aberrant expression of CaV1.1e in adults has been linked to the DM1 phenotype in mouse and human (Santoro et al., 2014; Tang et al., 2012), we subjected CaV1.1ΔE29 mice at 2 and 8 months of age to a range of behavioral tests to examine different aspects of muscle performance (Fig. 2).