Whereas a study in the Chinese Han population suggested that the two genetic variants (T -455C at rs2854116 and C-482 T at rs2854117) in the APOC3 were not associated with NAFLD risk, even did not contribute to the inter-individual differences in lipid profiles, insulin resistance, obesity, oxidative stress and susceptibility to NAFLD [47]. This evidence concerns the gene APOC3 and metabolic dysfunction-associated steatotic liver disease.