A case–control study in a community-based Han Chinese population highlight a missense variant in TM6SF2 rs58542926 is significantly contributes to increased NAFLD risk in Chinese population, independent of the Patatin-like phospholipase domain-containing 3 gene rs738409 and neurocan gene rs2228603 polymorphisms, but whether it is also involved in NAFLD disease progression and severity needed further investigation [77]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.