IL1RN and Alzheimer disease: In peripheral blood mononuclear cells (PBMC) from AD patients, incubated with Aβ, RvD1 promotes the phagocytosis of Aβ in vitro, inhibits apoptosis through the chemokine receptor G protein-coupled receptor 32 (GPR32), and promotes anti-inflammatory profiles by up-regulation of the interleukin 1 receptor antagonist (IL1RN), the integrin B 2 protein (ITGB2), and NF-κB expression, along with the down-regulation of pro-inflammatory cytokines, such as IL-1 and IL-6 [88].