APOE and Alzheimer disease: Interestingly, bexarotene also induces APOE ε4 lipidation, which increases the generation of APOE ε4–Aβ complexes and reduces Aβ pathology as well as synaptic damage in a mouse model expressing human APOE [120], suggesting a potential role of bexarotene for treating AD pathology and defective APOE ε4; however, bexarotene safety must be guaranteed [120].