For example, a study by Neill et al. suggested that IL-25 is more potent than IL-33 in activating ILC2s in vivo, as ILC2 expansion in mesenteric lymph nodes was less impaired in Ilrl1−/− (IL-33R subunit) mice than in Il17br−/− (IL-25R subunit) mice in response to helminth infection [31]. The gene discussed is IL33; the disease is helminthiasis.