TGFB1 and neoplasm: YY1 is a well-known, ubiquitously expressed transcription factor that plays various roles in different genes and cellular environments e.g., YY1 was found to positively regulate the expression of a wide range of genes such as BRCA1, TGF-β, and BACE1, with broad phenotypical effects such as tumor formation and progression of Alzheimer’s disease49, 50, 51.