Recently, CAPZA1, a member of the capping protein family, was reported to have prognostic value and a suppressive effect on cell migration and invasion in gastric cancer tissue [28], whereas the overexpression of actin-capping proteins has been shown to modulate cell motility in vitro, suggesting their potentially important role in promoting cell motility in the setting of pancreatic cancer [29]. Here, CAPZA1 is linked to familial pancreatic carcinoma.