It has been reported that about 50 % of individuals heterozygous for mutations in WNT10A display a phenotypic manifestation of abnormal Wnt signaling, such as abnormal shape or agenesis of one or several permanent teeth, nail dystrophy, dry skin, palmoplantar hyperkeratosis, sparse scalp hair, sparse eyelashes or sparse eyebrows [16]. This evidence concerns the gene WNT10A and Palmoplantar hyperkeratosis.