Ovarian cancer is characterised by dysregulation of multiple cellular signaling pathways involved in cancer initiation and progression, such as EGFR/ERBB [8], MAPK [9], PI3K/AKT/mTOR [6, 10], WNT [11], JAK/STAT [12], NFκB [13], ERα [14]. This evidence concerns the gene ESR1 and ovarian cancer.