Interestingly, only LXRα depletion significantly blunted the protective effects of YXS on MI/R-induced infarct size, while knockdown of PPARα, PPARβ and ERα only slightly blunted the effect of YXS on infarct size (Fig. 7E), suggesting that the favorable effect of YXS was mainly dependent on LXRα upregulation. This evidence concerns the gene ESR1 and myocardial infarction.