We speculate that aggNETs mayfurthermore provide a nidus of pancreatic stone formation53.Deficiency of neutrophil-mediated arginine citrullination and chromatindecondensation as in PADI4−/− mice protectsfrom pancreatitis in two distinct experimental models (IL-17A delivery, aggNETtransfer), whereas PADI4 deficiency cannot disrupt pancreatitis mediatedby acinar cell toxicity (caerulein). Here, IL17A is linked to pancreatitis.