PADI4 and pancreatitis: We observed that neutrophils may enter the lumen of biliopancreatic ducts underinflammatory conditions and form aggregates of NETs, which then hamper secretory flow,and thereby drive focal pancreatitis and parenchymal remodelling depending on PADI4.Cellular changes induced by components of the pancreatic juice, such as elevated levelsof bicarbonate, support PADI4 activity and induce H3cit+ NETformation.