Our previous work has shown that the expansion of IL-10-producing B cells correlates with disease suppression in bicongenic B6.NZBc1c4 mice and that transfer of B6.NZBc4 splenic B cells reduces the frequency of pro-inflammatory T cells in B6.NZBc1 lupus-prone recipient mice [7]. The gene discussed is IL10; the disease is systemic lupus erythematosus.