MMP2 and neoplasm: Agonists were able to induce increase in tumor vascularization even in the presence of DMSO, a solvent with known anti-angiogenic activity including, e.g., decrease of VEGF and pro-angiogenic matrix metalloproteinase-2 expression (observed also in this report, S1 Fig) and inhibition of endothelial cell proliferation [22, 37, 38].