To analyze the role of the individual adenosine receptors in B16F10 melanoma growth, we compared subcutaneous tumor growth rate in wild-type (WT), AOPCP-treated CD73 knockout mice (CD73-/- + AOPCP) and AOPCP-treated CD73-/- mice injected i.p. with specific A1, A2A, and A3 adenosine receptor agonists (CCPA, CGS-21680 or IB-MECA, respectively). This evidence concerns the gene NT5E and melanoma.