Compared to DMSO-treated WT mice and AOPCP-treated CD73-/- mice, stimulation of A3AR in CD73-depleted mice significantly increased macrophage infiltration of the tumor (9.7%, P<0.001 for both) whereas A2AAR stimulation had slightly lesser effect (6.6%, P<0.001 and P<0.01, respectively). This evidence concerns the gene NT5E and neoplasm.