A recent study examining cancerpleiotropy among DNA-repair and DNA-damage signalling pathway variants has alsoreported a highly significant association with lung cancer for rs3115672, asynonymous variant within MSH5, in addition to weaker associations withcolon and serous ovarian cancers (pleiotropic OR 1.18, 95% CI1.12-1.24, P=2.53 × 10−8)(Scarbrough et al, 2016). Here, MSH5 is linked to lung carcinoma.