MSH5 and Fanconi anemia: Gene-level analyses using the SKAT-C test from theSNP-set (Sequence) Kernel Association Test (SKAT) identified a significantassociation with PrCa for MSH5. Pathway-level analyses suggested apossible role for the translesion synthesis pathway in PrCa risk andHomologous recombination/Fanconi Anaemia pathway for PrCaaggressiveness, even though after adjustment for multiple testing these didnot remain significant.