Also in the present study two polymorphic sites in the CTLA4 gene i.e., exon 1: +49A/G and in the 3’ UTR region CT60A/G, were found to be associated with autoimmune hypothyroidism susceptibility in Gujarat population, as significant difference for genotype and allele frequency was observed between autoimmune hypothyroidism patients and controls (Tables 1 & 2). The gene discussed is CTLA4; the disease is Hashimoto thyroiditis.