Several polymorphic sites in the CTLA4 gene such as promoter -318 C/T[20], exon 1 +49 A/G [21, 22], microsatellite (AT)n repeat in the 3’-untranslated region (UTR) of exon [23] and three single nucleotide polymorphisms (SNPs) in the 6.1-kb 3’ non-coding region such as CT60, JO31 and JO30 have been reported to be associated with the organ-specific autoimmune disorders in several racial groups.[18, 24][25, 26] Among them, 3’ UTR CT60, -318 C/T and exon 1 +49 A/G SNPs are the highly polymorphic markers associated with autoimmune endocrinopathies [27]. The gene discussed is CTLA4; the disease is autoimmune disease.