Furthermore logistic regression analysis showed that, when adjusted for age and gender, AG and GG genotype of 3’UTR CT60 polymorphism of CTLA4 gene increase the risk of autoimmune hypothyroidism by 7.096 fold (95% CI: 1.616 to 31.171, p = 0.009) and 5.855 fold (95% CI: 1.467 to 23.368, p = 0.012) respectively (Table 2). The gene discussed is CTLA4; the disease is Hashimoto thyroiditis.