Furthermore logistic regression analysis showed that, when adjusted for age and gender, TC and CC genotype of 3’UTR CT60 polymorphism of CTLA4 gene increase the risk of autoimmune hypothyroidism by 7.729 fold (95% CI: 2.142 to 27.889, p = 0.002) and 15.151fold (95% CI: 3.303 to 69.507, p = 0.000) respectively (Table 2). Here, CTLA4 is linked to Hashimoto thyroiditis.