TREM1 and fungal infectious disease: TREM-1 expression has been reported in Aspergillus-containing granulomas, suggesting that this receptor might be involved in the antifungal responses of the host.[11] Further study indicated that TREM-1 regulates immune responses to A. fumigatus during fungal asthma in fungus-infected lungs, clearly revealing a role for TREM-1 in fungal infection [10].