SELP and Sepsis: For instance, platelet depletion had a protective effect in CLP model [51–53], and the modulation of platelet activation by using specific anti-P-selectin antibody [53] or drugs that inhibit platelet activation, such as clopidogrel, was beneficial [54] both in endotoxin shock [54] and polymicrobial sepsis [55], leading to hypothesize that anti-platelet drugs may represent a potential treatment in sepsis or acute respiratory distress syndrome [56].