In the current study, we observed several genes including SETD7 [25], DYRK2 [26], CCDC8 [27], and UBE2D1 [28] which are known to control TP53 protein stability and turnover through post-translational modifications and were epigenetically regulated in ACC tumors. This evidence concerns the gene UBE2D1 and adrenal cortex carcinoma.