These global methylation analyses suggested hypermethylation of tumor suppressors such as cyclin-dependent kinase inhibitor 2A (CDKN2A), Deleted in Lung and Esophageal Cancer 1 (DLEC1), or N-Myc Downstream-Regulated Gene family member 2 (NDRG2) as a mechanism for reduced mRNA expression observed in ACC tumors compared to adenomas or normal adrenal tissue. The gene discussed is CDKN2A; the disease is neoplasm.