STXBP1 mutations were first identified in children with early infantile epileptic encephalopathy with burst suppression (EIEE; also known as Ohtahara Syndrome) [1, 2] and subsequently found in patients diagnosed with other forms of epileptic encephalopathy including infantile spasms [3, 4], Lennox-Gastaut Syndrome [4], and Dravet Syndrome [5]. Here, STXBP1 is linked to early-infantile DEE.