Regarding Paracoccidioides spp., a recent study demonstrated that P. lutzii has a more active anaerobic metabolism than P. brasiliensis [66]; which correlates with the lower expression level of the studied SOD isoforms in P. lutzii. Since these cells have a reduced oxygen consumption they would most likely not have to synthesize such an elevated level of proteins related to oxidative stress defense as P. brasiliensis, particularly during host-pathogen interaction at the onset of the infection. This evidence concerns the gene SOD1 and infection.