CDC42 and pancreatic neoplasm: Since c.2587G>A mutant PLXNA1 in our study similarily increases pErk levels, but not MMP9 or markers of EMT, we would like to offer the observed SEMA3A-induced cytoskeletal re-organization and dysfunction via CDC42-mediated cofilin activation as possible PLXNA1 downstream signaling and mediator of increased migration in pancreas cancer.