Other studies linking genetic alterations of AG genes to a tumor promoting pro-survival role in pancreas cancer are a recent mutagenic transposon screen in mice, the detection of AG gene mutations in early precancerous lesions, genome wide association studies suggest genome-wide methylation patterns in pancreas cancer with recurrent perturbations in AG genes, or other correlative gene and protein expression studies in cancer specimens and clinical outcomes [9, 11–14]. This evidence concerns the gene RENBP and pancreatic neoplasm.