SNCA and multiple system atrophy: In summary, the motor and neuropathological analysis of the MSA transgenic mouse showed that, at the young age (PM3), the model replicates an early pre-motor phase of MSA-like pathology with presence of α-synuclein accumulation in oligodendrocytes but lack of neuronal loss in SN and striatum (two brain regions that are later affected by neurodegeneration) and respectively absence of motor deficits.