It is intriguing to compare the biological processes and modules involved in the pathogenesis of MSA versus PD while comparing the transcriptome analysis of striatum in MSA mice with oligodendroglial overexpression of α-synuclein to the transcriptome analysis of striatum in PD transgenic mice with neuronal overexpression of α-synuclein, both in a pre-manifestation phase of the disease [78]. The gene discussed is SNCA; the disease is Parkinson disease.