POMC and neoplasm: However, the highly vascular nature of the tumor and its potential for infiltration can make total resection difficult; recurrence is therefore a possibility.21 Under this circumstance, radiotherapy to control residual tumor and increase survival is recommended, although management is uncertain due to the rarity of this tumor.13 In our case, the ACTH and cortisol levels did not decrease to normal by 2 weeks after resection, although postoperative MRI showed a satisfying tumor removal.