Our results also confirm that IR is associated with an accelerate progression of liver fibrosis in CHC.1 Two independent groups46,47 found lower values for HOMA-IR in nondiabetic CHC patients carrying the rs12979860 CC IL28B genotype than in carriers of the other two possible genotypes (CT and TT), but our results and those of Degasperi et al48 and Lemoine et al49 do not confirm this relationship. This evidence concerns the gene IFNL3 and Hepatic fibrosis.