We also observed that miR-125a-5p functions as an oncogene in colon cancer cells via targeting Casp2 and P53. Furthermore, just like HOTAIR, the amount of miR-125a-5p in colon cancerous tissues was more than that in adjacent healthy tissues, and it was positively correlated with tumor size, lymph node metastasis and clinical stage. This evidence concerns the gene CASP2 and neoplasm.