AURKB and melanoma: Interestingly, a recent report suggested MAPK signaling-mediated transcriptional induction of Aurora kinase family member Aurora B.40 Although this finding together with a highly prevalent melanoma-associated MAPK signaling hyperactivity would argue for a similar mechanism of AURKA regulation, the early procurement of BRAF(V600E) in the evolution of melanoma cells, together with a correspondingly low AURKA levels in melanocytic nevi (Figure 2g) would argue against such regulatory axis.