Remarkably, the median lymphoma-free survival of Eμ-Myc;Rag-1-Cre;Mcl-1fl/+ mice (346 days) was far longer than in control Eμ-Myc (91 days) and Eμ-Myc;Rag-1-Cre mice (129 days, P**=0.003, Figure 4a), clearly demonstrating the importance of MCL-1 in c-MYC-induced lymphomagenesis. This evidence concerns the gene MCL1 and lymphoma.