Current studies report changes in the protein levels of TLR4 as well as of the MyD88 and TRIF adaptor molecules in pain models (paclitaxel-induced neuropathic pain [12] and cancer-induced bone pain [11, 12]); however, as far as we know, their protein levels of TLR4 as well as of the MyD88 and TRIF adaptor molecules have not been studied in neuropathic pain induced by CCI to the sciatic nerve in Wistar rats. The gene discussed is TLR4; the disease is cancer.