In an unrelated study by another group, aqueous fluid collected from 11 children with juvenile idiopathic arthritis-associated anterior uveitis was found to contain increased soluble ICAM-1, but not VCAM-1, in comparison to control fluid collected from children who did not suffer from uveitis.128 This finding suggests ICAM-1 may also be involved in B-cell migration across the iris vascular endothelium, as occurs in anterior uveitis. The gene discussed is ICAM1; the disease is uveitis.