In several human carcinogenic cell lines, such as colonic carcinoma cell lines HT29 [44] and COLO 201 [45], gastric adenocarcinoma cell line (SGC7901) [46], and hepatocellular carcinoma cell line (Hepa1-6) [47], resveratrol causes ER stress with upregulation of GRP78 and CHOP and a proapoptosis effect with elevated levels of phosphorylated elF2α and XBP-1 splicing. Here, HSPA5 is linked to hepatocellular carcinoma.