A connection between hsa-miR-375 and ER-α positivity was described in vitro [11, 31], in an interventional study in rodents [12] as well as in the clinical context of Tamoxifen resistance [31–34] and progression from normal tissue through lobular carcinoma in situ (LCIS) to invasive lobular carcinoma (ILC) [35]. The gene discussed is ESR1; the disease is invasive lobular breast carcinoma.