About one third of peripheral blood genes that differentiate rejection from stable function is regulated by TGFB [9], which is implicated in epithelial-to-mesenchymal transition, EMT, an integral part of chronic allograft nephropathy (CAN), podocyte dysfunction, proteinuria, and glomerulosclerosis [25,26]. This evidence concerns the gene TGFB1 and Crouzon syndrome-acanthosis nigricans syndrome.