Interestingly, one b-HCA with atypia harbored a CTNNB1 exon 3 deletion (Gly38_Thr40del) and a TP53 mutation (Ile251Phe), the latter located in a known ‘hotspot’ for cancer-related alterations and previously described in HCC [37]. The gene discussed is TP53; the disease is hepatocellular carcinoma.