To identifybiologically relevant mutations, we performed functional annotation clustering,using DAVID software, and found ABC transporter, NF-κB signaling,Notch signaling, and focal adhesion signaling clusters to be significantlydisturbed (Supplementary Table S3).This suggests that NF-κB signaling pathway genes among others, drivethe pathogenesis of Mef−/−Rad50s/s driven plasma cell neoplasm, as thesegenes are also significantly mutated in human multiple myeloma samples19. This evidence concerns the gene NFKB1 and plasma cell myeloma.