NHEJ hasbeen implicated in the development of multiple myeloma, with whole genome sequencing ofmultiple myeloma samples identifying a mutation in the coding region of the Mre11gene18, 19, and gene expression profiling of multiple myeloma cellsshowing increased expression of NHEJ-related genes, such as Rad50 andXrcc420. This evidence concerns the gene RAD50 and plasma cell myeloma.