In this pathway, the apoptosis regulator BCL-2 (PC-3p-36625_60-BCL2), Von Hippel-Lindau disease tumour-suppressor (miR-338-Vhl), transferrin receptor (miR-16a/20a-TFRC), MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 (miR-3618-SLC2A1), VEGF, and erythropoietin (EPO) expression were significantly up-regulated, which is additional evidence of an up-regulated HIF-1 signaling pathway. The gene discussed is VEGFA; the disease is von Hippel-Lindau disease.