Of the 66 known type 2 diabetes variants we only found evidence of deviation from additivity for the SNP rs7756992 at the CDKAL1 locus (MAF = 0.27; pDOMDEV = 5 × 10−4) (Fig. 2, Table 4 and ESM Table 5). The gene discussed is CDKAL1; the disease is type 2 diabetes mellitus.