A common polymorphism in the CFH gene (c.1277T>C, p.Tyr402His) is highly associated with the development of AMD; the CFH p.Tyr402His variant (in following termed CFHH402) increases the risk for AMD ∼2–4-fold for heterozygous and 5–7-fold for homozygous individuals32, 33, 34. The gene discussed is CFH; the disease is age-related macular degeneration.