Some of these genes were reported to be useful in differential diagnosis of other forms of tumors such as FN1 as a marker for renal cell carcinoma aggressiveness [37], PRAME as a marker for differentiating Müllerian carcinoma from malignant mesothelioma [38] and ABCA8 as part of a multigene gene assay for classifying cancer types [39]. Here, PRAME is linked to hereditary clear cell renal cell carcinoma.