APOE and type 2 diabetes mellitus: Aggregated Aβ, hyperphosphorylated tau, ubiquitin, apolipoprotein E, apolipoprotein(a), IB1/JIP-1 and JNK1 are immuno-expressed in the affected Langerhans islets in patients with type 2 diabetes [82, 85, 86] and Aβ is colocalized with amylin [82].