Of note, the HER-2-specific cytotoxic CD8 response was three- to fourfold higher in the tumor/lungs than in the spleen, while the virus-targeted response (i.e., stimulated by MVA-specific E3L and F2L peptides) alone or in combination with anti-CTLA-4 was similar in both tissues. This evidence concerns the gene ERBB2 and neoplasm.