HSPB8 also participates in the clearance of other misfolded proteins responsible for neurodegenerative diseases (NDs), such as two polyglutamine-containing proteins: mutant huntingtin responsible for Huntington Disease (HD) and ataxin-3 responsible for Spinal Cerebellar Ataxia 3 (SCA-3)10, as well as of beta-amyloid involved in Alzheimer’s disease (AD)39 and of alpha-synuclein involved in Parkinson’s disease (PD)40, 41. This evidence concerns the gene HSPB8 and Huntington disease.